Sample Processing and Downstream Analysis Some clinical samples, such as skin swabs, are typically limited in volume and have a low abundance of viruses as well as a high background from the host microbiome. The entire process, from sample collection to sequencing, will impact the detection of viral sequences and needs to be carefully tailored […]
Protein engineering describes the process of altering the structure of an existing protein to improve its properties. It is an important technology that increases our basic understanding of how enzymes function and have evolved, and it is the key method of improving enzyme properties for applications in pharmaceuticals, green chemistry, and biofuels. Protein engineering can […]
Chemical Threats and Toxidromes The civilian chemical threat spectrum includes chemical warfare agents, toxic industrial chemicals, pesticides, and other chemicals. These chemical threats have a diverse spectrum of effects. The cholinesterase and GABA-inhibiting chemical agents induce prolonged and uncontrolled excitation of the nervous system and include the CWAs sarin, soman, and VX, as well as […]
Molecular representation An important decision before undertaking either generative or predictive modeling of molecules is the choice of representation. Transforming a molecule into vectors of numbers that can be accepted by learning systems is called molecular featurization Four kinds of forms that describe molecules can be inputted into DL models: molecular descriptors (e.g. logP, polar […]
The relationship between privacy and control Privacy is a concept that has been considered and defined in very different disciplines, from descriptive, empirical, and normative perspectives (Sevignani, 2016; Trepte & Reinecke, 2011). In earlier days, privacy was considered a human right and identified as the “right to be let alone” (Warren & Brandeis, 1890, p. […]